Blade: The Series follows the adventures of the half-human, half-vampire vampire-hunter, Blade (Kirk "Sticky" Jones, Over There), as he fights to prevent the takeover of vampires over mankind. At his side is Krista Starr (Jill Wagner, Punk'd), an ex-military veteran who seeks vengeance against all vampires due to the death of her brother, and his gadget-man, Shen (Nelson Lee, Traffic), who aid him in his quest. Blade's main adversary in this series is Marcus Van Sciver (Neil Jackson, Dream Team), who is the leader of the house of Chthon.

• Sticky Fingaz
• Jill Wagner
• Nelson Lee
• Jessica Gower
• Neil Jackson